Potential Use of Lactobacillus gasseri G10 Isolated from Human Vagina along with Intrauterine Devices (IUD) to Prevent Pathogen Colonization

Intrauterine devices (IUDs), well effective long-term contraception methods used around the world, are potential reservoir for pathogens and carry risk of reproductive-tract infections such as bacterial vaginosis vulvovaginal candidiasis. A healthy vagina is dominated by Lactobacillus involved in protecting reproductive system against pathogens. This study aims to investigate impact L. gasseri G10 (G10), a vaginal isolate, its Exopolysaccharide (EPS) on adherence Staphylococcus aureus Candida albicans IUD-tail. Three conditions were simulated examine if with/without EPS capable displacing, excluding, competing pathogen adhesion IUD. Inhibitory at various concentrations was also evaluated with co-incubation. blocked co-incubation (97%) displacement (46%) S. IUD tail displaced C. attached about 99%. Compared aureus, biofilm formation highly susceptible EPS. All inhibited (81-97%); however, no significant reductions observed adherence. Moreover, together reduced both (>99%) (94-98%) through all three mechanisms. indicates that have ability inhibit use intravaginal products prevent/manage associated women. The results suggest development new way applying along probiotic agents alone or synbiont.